SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1; S M Jeong, J Lee, L W S Finley, P J Schmidt, M D Fleming and M C Haigis; Oncogene advance online publication 9 June 2014; doi: 10.1038/onc.2014.124

The activity of SIRT3 is inhibited in frataxin-deficient heart, it may contribute to the cardiomyopathy in Friedreich’s ataxia. Friedreich’s ataxia cells exhibit an increased IRP1 activity and iron accumulation, thus, it will be interesting for future studies to examine the role of SIRT3 in systemic iron homeostasis and iron-related human diseases.