Autophagy in neurodegenerative diseases: from pathogenic dysfunction to therapeutic modulation

Autophagy in neurodegenerative diseases: from pathogenic dysfunction to therapeutic modulation. Marta Martinez-Vicente, Seminars in Cell & Developmental Biology, Available online 2 April 2015, ISSN 1084-9521, http://dx.doi.org/10.1016/j.semcdb.2015.03.005.

Autophagic dysfunction has been described in many neurodegenerative diseases, ranging from Alzheimer’s disease (AD), to Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia and others. Failure of the autophagic process may thus be one of the factors contributing to neuronal cell death