Cardioprotective HIF-1α-frataxin signaling against ischemia-reperfusion injury.

Cardioprotective HIF-1α-frataxin signaling against ischemia-reperfusion injury. Gayani Nanayakkara , Abdullah Alasmari , Shravanti Mouli , Haitham Eldoumani , John C. Quindry , Graham McGinnis , Xiaoyu Fu , Avery Berlin , Bridget Peters , Juming Zhong , Rajesh H. Amin, American Journal of Physiology - Heart and Circulatory Physiology Published 12 June 2015 Vol. no. , DOI: 10.1152/ajpheart.00875.2014

we postulated that HIF-1α transcriptionally regulates frataxin expression in response to hypoxia