Wednesday, March 9, 2016

Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34

Shen Y, McMackin MZ, Shan Y, Raetz A, David S, Cortopassi G. PLoS ONE 11(3): e0151026. doi:10.1371/journal.pone.0151026

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We hypothesized that frataxin deficiency increases DNA damage and DNA repair genes specifically in microglia, activating them. siRNA-mediated frataxin knockdown in microglial BV2 cells clearly elevated DNA damage and the expression of DNA repair genes MUTYH and PARP-1


 Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34