Characterization of frataxin gene network in Friedreich's ataxia fibroblasts using the RNA-Seq technique

Noëlia Sanchez, Pierre Chapdelaine, Joël Rousseau, Frédéric Raymond, Jacques Corbeil, Jacques P. Tremblay, Mitochondrion, Available online 25 June 2016, ISSN 1567-7249, doi:10.1016/j.mito.2016.06.003

The study identified key players of FXN gene regulatory network and highlighted the role of FXN in the regulation of hemostasis, angiogenesis, interferon-induced apoptosis and DNA damage in FRDA. Since no efficient cure exists to treat FRDA patients, understanding the regulatory network of FXN is requisite to develop promising therapies for this debilitating condition.
This work provides valuable insight into the regulatory network of frataxin and may open new avenues for gene therapy of Friedreich's ataxia.

 Characterization of frataxin gene network in Friedreich's ataxia fibroblasts using the RNA-Seq technique