Histone deacetylase inhibitors modulating non-epigenetic players: The novel molecular targets for therapeutic intervention

Shabir Ahmad Ganai. Current Drug Targets, Volume 17 DOI: 10.2174/1389450117666160527143257

Emerging evidences suggest that acetylation of non-histone proteins plays a critical role in various cellular processes including mRNA stability, protein localization and degradation. Abnormal turnover or expression of non-histone proteins like nuclear factor- kappaB (NF-кB), heat shock protein 90 (HSP90) and frataxin fuels various diseases including cancer.

 Histone deacetylase inhibitors modulating non-epigenetic players: The novel molecular targets for therapeutic intervention