Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters

Merav Darash-Yahanaa, Yair Pozniakb, Mingyang Luc, Yang-Sung Sohn, Ola Karmi, Sagi Tamir, Fang Bai, Luhua Song, Patricia A. Jennings, Eli Pikarsky, Tamar Geiger, José N. Onuchic, Ron Mittler and Rachel Nechushtai, PNAS early/2016/09/07, DOI:10.1073/pnas.1612736113

Freely available online through the PNAS open access option.

Disrupted expression of frataxin, another protein involved in Fe-S biogenesis, in hepatocytes of transgenic mice similarly led to impaired mitochondrial function, oxidative stress, and the development of multiple hepatic tumors. Moreover, ISCU and frataxin are regulated at the transcriptional level by p53 controlling the levels of ROS in cells

 Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters