Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control

Michela Guaraldo, Paolo Santambrogio, Elisabetta Rovelli, Augusta Di Savino, Giuseppe Saglio, Davide Cittaro, Antonella Roetto & Sonia Levi; Scientific Reports 6, Article number: 33432 (2016) doi:10.1038/srep33432

The reagents Aza and NaB make the DNA accessible to transcription factors and activate FTMT expression. Our findings sustain that the moderate induction of FTMT expression by epigenetic therapy could be useful in disease characterized by oxidative stress, as FRDA.
 Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control