Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury

Xiaodong Yang, Shaoqing Xu, Yiwei Qian, Qin Xiao, Brain, Behavior, and Immunity, Available online 6 March 2017, ISSN 0889-1591, doi:10.1016/j.bbi.2017.03.003.

Microglia are the primary cells that exert immune function in the central nervous system (CNS), and accumulating evidence suggests that microglia act as key players in the initiation of neurodegenerative diseases.
We propose that overexpression PGC-1α by resveratrol could be a potential therapeutic approach to suppress neuroinflammation by regulating microglia polarization.


Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury