Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity

Pablo Calap-Quintana, Javier González-Fernández, Noelia Sebastiá-Ortega, José Vicente Llorens, Orcid and María Dolores Moltó; Int. J. Mol. Sci. 2017, 18(7), 1456; doi:10.3390/ijms18071456

Drosophila models of FRDA support the proposal that iron plays a major role in FRDA physio-pathology. Although reduction in iron levels by iron chelation has been relatively successful in clinical trials, genetic or pharmacological intervention through the sphingolipid/Pdk1/Mef-2 pathway and pathways regulating iron homeostasis are new approaches to be explored in preclinical studies.

 Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity