Magnetic susceptibility of the dentate in a longitudinal study of Friedreich ataxia

Phillip G D Ward, Ian H Harding, Parnesh Raniga, Tom G Close, Louise A Corben, Martin B Delatycki, Monique R Stagnitti, Elsdon Storey, Nellie Georgiou-Karistianis, and Gary F Egan; International Society for Magnetic Resonance in Medicine, (Abstract #3731) 16-21 June 2018 Paris (France)

We performed in-vivo measurements of the magnetic susceptibility in the dentate nucleus in individuals with Friedreich ataxia and healthy controls over a two-year longitudinal study using quantitative susceptibility mapping. The results show a significant susceptibility difference between individuals with Friedreich ataxia and control subjects, and a strong correlation with disease severity in the Friedreich ataxia cohort. These findings may lead to the development of a sensitive biomarker of disease severity and progression in Friedreich ataxia.

Magnetic susceptibility of the dentate in a longitudinal study of Friedreich ataxia