Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels.

Indrajit Bandyopadhyay, Sandipan Roy Chowdhury, Nishant P. Visavadiya, Sidney M. Hecht, Omar M. Khdour, Data in Brief, Volume 20, 2018,
Pages 1105-1114, doi:10.1016/j.dib.2018.08.156

As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich’s ataxia cells . This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.

 Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels.