Microvascular pathology in Friedreich cardiomyopathy

Arnulf H. Koeppen, Jiang Qian, Alicia M. Travis, Alyssa B. Sossei, Paul J. Feustel and Joseph E. Mazurkiewicz; Histol Histopathol. 2019 Jun 5:18132. doi: 10.14670/HH-18-132. [Epub ahead of print]


Heart disease is an integral part of Friedreich ataxia (FA). In addition to cardiomyocyte hypertrophy, fiber necrosis, and inflammatory infiltration, sections show fibrosis and disorganized capillaries. We examined the left ventricular wall (LVW) of 41 homozygous and 2 compound heterozygous FA patients aged 10-87 and 21 controls aged 2-69.

Microvascular pathology in Friedreich cardiomyopathy