Oxidative post‐translational modifications in histones

José Luis García‐Giménez, Carlos Romá‐Mateo, Federico V. Pallardó; Biofactors. 2019 Jun 11. doi: 10.1002/biof.1532.

Epigenetic regulation is attracting much attention because it explains many of the effects that the external environment induces in organisms. Changes in the cellular redox status and even more specifically in its nuclear redox compartment is one of these examples. Redox changes can induce modulation of the epigenetic regulation in cells. Here we present a few cases where reactive oxygen or nitrogen species induces epigenetic marks in histones. Posttranslational modification of these proteins like histone nitrosylation, carbonylation, or glutathionylation together with other mechanisms not reviewed here are the cornerstones of redox‐related epigenetic regulation. We currently face a new field of research with potential important consequences for the treatment of many pathologies.



Oxidative post‐translational modifications in histones