Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity

Peverill RE, Romanelli G, Donelan L, Hassam R, Corben LA, Delatycki MB (2019); PLoS ONE 14(11): e0225147. doi:10.1371/journal.pone.0225147

In FRDA, increases in RWT and age-normalized RWT are the most frequent LV structural abnormalities, sex and body size are important determinants of most other LV structural variables in both children and adults, and increased genetic severity is associated with a smaller left ventricle and increased LV wall thickness in adults, but not associated with LV size or wall thickness in children.

Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity