N-terminomics/TAILS profiling of macrophages after chemical inhibition of legumain

Bethany M AndersonLuiz G. N. de AlmeidaHenna SekhonDaniel YoungAntoine DufourLaura Edgington-Mitchell; Biochemistry 2019, XXXX, XXX, XXX-XXX, Publication Date: November 14, 2019 doi:10.1021/acs.biochem.9b00821

We confirmed that frataxin, a mitochondrial protein associated with the formation of iron-sulfur clusters, can be cleaved by legumain. This further asserts a potential contribution of legumain to mitochondrial function and iron metabolism.

N-terminomics/TAILS profiling of macrophages after chemical inhibition of legumain