Monday, March 29, 2021
Pre-clinical left ventricular myocardial remodeling in patients with Friedreich's ataxia: A cardiac MRI study
Takazaki KAG, Quinaglia T, Venancio TD, Martinez ARM, Shah RV, Neilan TG, Jerosch-Herold M, Coelho-Filho OR, França MC Jr.; PLoS One. 2021 Mar 26;16(3):e0246633. doi: 10.1371/journal.pone.0246633.
LV hypertrophy and concentric LV remodeling in FRDA are associated at the tissue level with an expansion of the ECV and an increase in cardiomyocyte size. The adverse tissue remodeling assessed by ECV and τic is associated with more severe cardiomyopathy classification, suggesting a role for these markers in tracking disease progression.
