Hsa-miR223-3p circulating level is upregulated in Friedreich’s ataxia and inversely associated with HCLS1 associated protein X-1, HAX-1

Andrea Quatrana, Elena Morini, Francesca Tiano, Chiara Vancheri, Luca Panarello, Silvia Romano, Christian Marcotulli, Carlo Casali, Caterina Mariotti, Alessia Mongelli, Mario Fichera, Alessandra Rufini, Ivano Condò, Giuseppe Novelli, Roberto Testi, Francesca Amati, Florence Malisan; Human Molecular Genetics, 2022;, ddac005, doi:10.1093/hmg/ddac005 

This study describes for the first time the association between hsa-miR223-3p and HAX-1 expression in FRDA, thus supporting a potential role of this microRNA as non-invasive epigenetic biomarker for FRDA.

Hsa-miR223-3p circulating level is upregulated in Friedreich’s ataxia and inversely associated with HCLS1 associated protein X-1, HAX-1