Iron dysregulation ranges from iron deficiency to iron overload and is seen in many types of cardiovascular disease, including heart failure, myocardial infarction, anthracycline-induced cardiotoxicity, and Friedreich’s ataxia. Recently, the use of intravenous iron therapy has been advocated in patients with heart failure and certain criteria for iron deficiency. Here, we provide an overview of systemic and cellular iron homeostasis in the context of cardiovascular physiology, iron deficiency, and iron overload in cardiovascular disease, current therapeutic strategies, and future perspectives.
Sunday, February 5, 2023
Iron Metabolism in Cardiovascular Disease: Physiology, Mechanisms, and Therapeutic Targets
Konrad Teodor Sawicki, Adam De Jesus and Hossein Ardehali; Circulation Research. 2023;132:379–396, doi:10.1161/CIRCRESAHA.122.321667
