The most critical GSH requirement was assigned to Atm1-dependent export, i.e. a step before GSH-dependent cGrxs function. Our findings extend the general model of eukaryotic Fe/S protein biogenesis by adding the molecular requirements for cytosolic [2Fe-2S] protein maturation.
Sunday, June 2, 2024
Requirements for the biogenesis of [2Fe-2S] proteins in the human and yeast cytosol
Braymer JJ, Stehling O, Stümpfig M, et al. Requirements for the biogenesis of [2Fe-2S] proteins in the human and yeast cytosol. Proceedings of the National Academy of Sciences of the United States of America. 2024 May;121(21):e2400740121. DOI: 10.1073/pnas.2400740121. PMID: 38743629; PMCID: PMC11126956.
