Lower mitochondrial OXPHOS capacity, inactivity, and visceral adiposity contribute to lower insulin sensitivity in FRDA. Higher insulin secretion appears compensatory, and when inadequate, could herald DM. Further studies are needed to determine if muscle- or adipose-focused interventions could delay FRDA-related DM.
Thursday, August 8, 2024
Insulin sensitivity and insulin secretion in adults with Friedreich’s Ataxia: the role of skeletal muscle
Jaclyn Tamaroff, Sara Nguyen, Neil E Wilson, Darko Stefanovski, Rui Xiao, Theresa Scattergood, Christopher Capiola, Gayatri Maria Schur, Julia Dunn, Anna Dedio, Kristin Wade, Hardik Shah, Rohit Sharma, Vamsi K Mootha, Andrea Kelly, Kimberly Y Lin, David R Lynch, Ravinder Reddy, Michael R Rickels, Shana E McCormack, Insulin sensitivity and insulin secretion in adults with Friedreich’s Ataxia: the role of skeletal muscle, The Journal of Clinical Endocrinology & Metabolism, 2024;, dgae545, doi:10.1210/clinem/dgae545
