Our study confirms the typical NfL profile in FRDA patients. Our data further support the role of NfL as early indicator of axonal damage and as potential pharmacodynamic biomarker of therapeutical response especially valuable in pediatric populations.
Friday, September 26, 2025
Impact of age on neurofilament light chain in Friedreich ataxia: a 1-year longitudinal study
Petrillo S, Mongelli A, Castaldo A, Sarro L, Azzarelli S, Ronco R, Castellotti B, Gellera C, Piemonte F, Mariotti C. Impact of age on neurofilament light chain in Friedreich ataxia: a 1-year longitudinal study. Brain Commun. 2025 Sep 10;7(5):fcaf331. doi: 10.1093/braincomms/fcaf331. PMID: 40994821; PMCID: PMC12455201.
