From Mutations to Microbes: Investigating the Impact of the Gut Microbiome on Repeat Expansion Disorders

Das S, Patel M, Khandelwal S, Rawat R, Shukla S, Kumari AP, Singh K, Kumar A. From Mutations to Microbes: Investigating the Impact of the Gut Microbiome on Repeat Expansion Disorders. J Neurochem. 2025 Nov;169(11):e70278. doi: 10.1111/jnc.70278. PMID: 41194479. 

 Alterations in microbial diversity and composition have been observed across multiple REDs; however, a comprehensive understanding of the complete scenario remains a significant challenge. To elucidate these dynamic interactions, future research should utilize multifaceted approaches. This review focuses on the key modifications in the gut microbiome that contribute to the pathogenesis of REDs and discusses potential gut microbiome-targeted therapeutic strategies that could be effectively employed to treat these disorders.

From Mutations to Microbes: Investigating the Impact of the Gut Microbiome on Repeat Expansion Disorders