Pathological frataxin deficiency in mice causes tissue-specific alterations in iron homeostasis

Pazos-Gil M, Medina-Carbonero M, Sanz-Alcázar A, Portillo-Carrasquer M, Oliveira-Jorge L, Hernández G, Sánchez M, Delaspre F, Cabiscol E, Ros J, Tamarit J. Pathological frataxin deficiency in mice causes tissue-specific alterations in iron homeostasis. iScience. 2026 Jan 5;29(2):114625. doi: 10.1016/j.isci.2025.114625. PMID: 41623463; PMCID: PMC12857413.

In this study, we have analyzed iron homeostasis in a mouse model presenting pathological frataxin deficiency (FXNI151F). Our results reveal tissue-specific alterations of iron regulatory proteins (IRPs).

Pathological frataxin deficiency in mice causes tissue-specific alterations in iron homeostasis