Monday, April 27, 2026

Nomlabofusp Treatment Produces Frataxin Levels That Correlate Across Peripheral Tissues: Preclinical and Clinical Support for Surrogate Tissue Sampling

De Toni F, Hamdani M, Patadia C, Shankar G. Nomlabofusp Treatment Produces Frataxin Levels That Correlate Across Peripheral Tissues: Preclinical and Clinical Support for Surrogate Tissue Sampling. Clin Transl Sci. 2026 May;19(5):e70565. doi: 10.1111/cts.70565. PMID: 42033121; PMCID: PMC13109711. 

This study evaluated whether nomlabofusp‐derived hFXN concentrations covary across accessible peripheral matrices and FRDA‐relevant tissues, supporting the feasibility of surrogate tissue sampling to monitor drug‐derived hFXN exposure.