Recent discoveries reveal that frataxin (FXN) and ferredoxin 2 (FDX2) competitively regulate mitochondrial iron–sulfur (Fe–S) cluster biosynthesis through their binding to the cysteine desulfurase NFS1 and the iron-sulfur cluster scaffold protein ISCU2 complex. Here, we discuss the potential of rationally designed peptide inhibitors targeting the FDX2–NFS1 interaction as a strategy to mitigate FXN deficiency and restore Fe–S cluster biosynthesis.
Monday, May 25, 2026
Targeting competitive Fe–S regulation to treat Friedreich’s ataxia
Campos J, Ferreira J.
Targeting competitive Fe–S regulation to treat Friedreich’s ataxia.
Trends in Pharmacological Sciences, 2026; 0 DOI: 10.1016/j.tips.2026.04.010
