Allosteric rewiring of mitochondrial stress signaling through Miro1

Drwesh L, Fitzgerald J; Allosteric rewiring of mitochondrial stress signaling through Miro1: Cell Chemical Biology, 33, 1071-1073. doi:10.1016/j.chembiol.2026.07.011 

 Mitochondrial dysfunction is a common feature of both inherited mitochondrial disorders and neurodegenerative diseases. Although these disorders differ clinically, many converge on shared underlying pathobiology, including oxidative damage, impaired mitochondrial homeostasis, and defective mitochondrial quality control. Chandra and colleagues investigate these shared stress pathways in the context of Friedreich’s ataxia.

Allosteric rewiring of mitochondrial stress signaling through Miro1