Risk/Benefit assessment, advantages over other drugs and targeting methods in the use of deferiprone as a pharmaceutical antioxidant in iron loading and non iron loading conditions.

Hemoglobin. 2009;33(5):386-97.

Kontoghiorghes GJ, Efstathiou A, Kleanthous M, Michaelides Y, Kolnagou A.

Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus.

Keywords: oxidative stress, brain, heart, liver, kidneys, classical antioxidants, deferiprone, mobilizing labile iron and copper, free radicals, high therapeutic index, tissue penetration, rapid iron binding, clearance, iron complex, toxicity, cardiomyopathy, thalassemia, diabetic nephropathy, glomerulonephritis, kidney disease, Friedreich's Ataxia, Fanconi Anemia, deferoxamine (DFO), deferasirox (DFRA).

Friedreich ataxia: a computational dynamic model of the key proteins involved in the yeast Fe–S cluster biogenesis

Friedreich ataxia: a computational dynamic model of the key proteins involved in the yeast Fe–S cluster biogenesis
New Biotechnology
Volume 25, Supplement 1, September 2009, Pages S342-S343
Abstracts of the 14th European Congress on BiotechnologyBarcelona, Spain 13–16 September, 2009

I. Amela1, J. Cedano1, P. Delicado2 and E. Querol1

1Universitat Autònoma de Barcelona, Bellatera - Barcelona, Spain

2Universitat Politècnica de Catalunya, Barcelona, Spain

Characterizing gait, locomotor status, and disease severity in children and adolescents with friedreich ataxia.

J Neurol Phys Ther. 2009 Sep;33(3):144-9.

Croarkin E, Maring J, Pfalzer L, Harris-Love M, Siegel K, Diprospero N.
National Institutes of Health (E.C., K.S.), Bethesda, MD; George Washington University, Physical Therapy Program (J.M., M.H.L.), Washington, DC; University of Michigan School of Health Related Professions and Studies (L.P.), Ann Arbor, Michigan; and National Institute of Neurological Disorders and Stroke (N.D.P.), Bethesda, Maryland.

KEYWORDS: gait parameters, children, adolescents, Friedreich ataxia (FA), disease severity, Friedreich Ataxia Rating Scale (FARS), walk.

Mystery About Proteins That Package The Genome Solved

Florida State University. "Mystery About Proteins That Package The Genome Solved." ScienceDaily 8 October 2009

Keywords: regulate gene expression, histones, packaging DNA, genes are turned on or off,

Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

Nature Medicine 15, 1215 - 1218 (2009)
Published online: 13 September 2009 | doi:10.1038/nm.2025

Yong Hong Chen¹, Michael Chang² & Beverly L Davidson^1,3

1. Department of Internal Medicine, Iowa City, Iowa, USA.
2. Departments of Molecular Physiology & Biophysics, Iowa City, Iowa, USA.
3. Department of Neurology, University of Iowa, Iowa City, Iowa, USA.

Keywors: Brain vasculature,  neural cells, microvessel,  enzyme replacement therapy, central nervous system (CNS), endothelia,  neurons,  glia, adeno-associated virus (AAV),  biodistribution.

Glutaredoxins: roles in iron homeostasis

Trends in Biochemical Sciences
Article in Press,
 
Nicolas Rouhier1, , Jérémy Couturier1, Michael K. Johnson2 and Jean-Pierre Jacquot1


1Unité Mixte de Recherches 1136 INRA Nancy University, Interactions Arbres Microorganismes, IFR 110 EFABA, Faculté des Sciences, BP 239 54506, Vandoeuvre Cedex, France
2Department of Chemistry and Center for Metalloenzyme Studies, University of Georgia, Athens, GA 30602, USA


Available online 5 October 2009.

Mitochondria - A neglected drug target.

Curr Opin Investig Drugs. 2009 Oct;10(10):1022-4.Links

Murphy MP.

Medical Research Council Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK. mpm@mrc-mbu.cam.ac.uk.

No Link Between Suicide and Stop-Smoking Drugs

By Kristina Fiore, Staff Writer, MedPage Today
Published: October 02, 2009
Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco. 

Keywords:  varenicline (Chantix)

Diverse effects in Friedreich's ataxia place PGC-1alpha center-stage.

Clin Genet. 2009 Oct;76(4):345-7
Metzler M.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Vancouver, BC, Canada. martina@cmmt.ubc.ca

Biophysical Characterization of the Iron in Mitochondria from Atm1p-Depleted Saccharomyces cerevisiae

Biochemistry, Article ASAP DOI: 10.1021/bi901110n
Publication Date (Web): September 17, 2009
 
Ren Miao, Hansoo Kim, Uma Mahendra Kumar Koppolu, E. Ann Ellis, Robert A. Scott and Paul A. Lindahl*

‡ Department of Chemistry § Microscopy and Imaging Center,
Department of Biochemistry and Biophysics
Texas A&M University, College Station, Texas 77843-3255
Department of Chemistry, University of Georgia, Athens, Georgia 30602-2556

Keywords: Atm1p, ABC transporter, mitochondrial inner membrane, cytosol, cellular iron metabolism, cytosolic Fe/S cluster assembly, mitochondrial Fe/S cluster assembly,  Mssbauer spectroscopy, EPR, electronic absorption spectroscopy, X-ray absorption spectroscopy, and electron microscopy, aerobically grown cells, iron(III) phosphate nanoparticles,  yeast frataxin Yfh1p-deleted, yeast ferredoxin Yah1p-depleted,  Atm1p-depleted, nonheme Fe(II) ions, oxidative damage,  cytosolic Fe/S cluster assembly,  oxygen.