Medical News Today, Article Date: 17 Jul 2010
"EPO drug development for the brain is limited, because EPO does not cross the blood-brain barrier (BBB)"
"EPO-driven neuroprotection in human brain disorders is now possible with systemic administration of the HIRMAb-EPO fusion protein at doses that have minimal effects on erythropoiesis."
ArmaGen® Web
Sunday, July 18, 2010
Thursday, July 15, 2010
Oxidative stress, thiol redox signaling methods in epigenetics.
Methods Enzymol. 2010; 474: 213-44, doi:10.1016/S0076-6879(10)74013-1
Sundar IK, Caito S, Yao H, Rahman I
Keywords: Epigenetics, gene expression, posttranslational modifications, histones, histone acetylation, deacetylation, methylation, histone acetyltransferases (HATs), histone deacetylases (HDACs), reative oxygen species (ROS), signaling pathways, SIRT1.
Sundar IK, Caito S, Yao H, Rahman I
Keywords: Epigenetics, gene expression, posttranslational modifications, histones, histone acetylation, deacetylation, methylation, histone acetyltransferases (HATs), histone deacetylases (HDACs), reative oxygen species (ROS), signaling pathways, SIRT1.
Tuesday, July 13, 2010
Heterochromatin dysregulation in human diseases
doi:10.1152/japplphysiol.00053.2010
Munich Center for Integrated Protein Science (CiPSM) and Adolf-Butenandt-Institute, Ludwig-Maximilians-University, Munich, Germany
Keywords: epigenetics, heterochromatin, epigenetic therapy, FSHD, Friedreich's ataxia (FRDA), cancer
Sunday, July 11, 2010
The Intermembrane Space of Mitochondria
Antioxidants & Redox Signaling. doi:10.1089/ars.2009.3063.
Johannes M. Herrmann and Jan Riemer
Johannes M. Herrmann and Jan Riemer
Department of Cell Biology, University of Kaiserslautern, Kaiserslautern, Germany.
Saturday, July 10, 2010
Review: Friedreich Ataxia and Erythropoietin
The Open Drug Discovery Journal, Volume 2, ISSN: 1877-3818
Review: Friedreich Ataxia and Erythropoietin, pp.18-24 (7)
Authors: Sylvia Boesch, Brigitte Sturm, Wolfgang Nachbauer, Sascha Hering, Hannes Steinkellner, Rainer Schneider, Werner Poewe, Barbara Scheiber-Mojdehkar
doi: 10.2174/1877381801002020018
FULL TEXT PDF
Review: Friedreich Ataxia and Erythropoietin, pp.18-24 (7)
Authors: Sylvia Boesch, Brigitte Sturm, Wolfgang Nachbauer, Sascha Hering, Hannes Steinkellner, Rainer Schneider, Werner Poewe, Barbara Scheiber-Mojdehkar
doi: 10.2174/1877381801002020018
FULL TEXT PDF
Tuesday, July 6, 2010
Iron-Overload Cardiomyopathy: Pathophysiology, Diagnosis, and Treatment
Journal of Cardiac Failure, Article in Press, Corrected Proof. Available online 3 July 2010.
Colm J. Murphy MD, FRCPC and Gavin Y. Oudit MD, PhD, FRCPC
Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
Keywords: Cardiomyopathy; hemochromatosis; oxidative stress; anemia; cardiac MRI; echocardiography; primary (hereditary) hemochromatosis; secondary iron overload (hemosiderosis); iron toxicosis (iron poisoning); myocardial ischemia-reperfusion injury; cardiomyopathy associated with Friedreich ataxia; vascular dysfunction.
Colm J. Murphy MD, FRCPC and Gavin Y. Oudit MD, PhD, FRCPC
Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
Keywords: Cardiomyopathy; hemochromatosis; oxidative stress; anemia; cardiac MRI; echocardiography; primary (hereditary) hemochromatosis; secondary iron overload (hemosiderosis); iron toxicosis (iron poisoning); myocardial ischemia-reperfusion injury; cardiomyopathy associated with Friedreich ataxia; vascular dysfunction.
Monday, July 5, 2010
The Role of PGC-1alpha in the Pathogenesis of Neurodegenerative Disorders
Curr Drug Targets. 2010 Jul 1
Róna-Vörös K, Weydt P.
Department of Neurology, Ulm University, Ulm, Germany
Keywords: Mitochondrial dysfunction, neurodegeneration, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), transcriptional co-activator PGC-1alpha.
Róna-Vörös K, Weydt P.
Department of Neurology, Ulm University, Ulm, Germany
Keywords: Mitochondrial dysfunction, neurodegeneration, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), transcriptional co-activator PGC-1alpha.
Thursday, July 1, 2010
Assessment of impairment or monitoring change in Friedreich ataxia
Movement Disorders, 10.1002/mds.23103
Letter to the Editor
Adam P. Vogel, MSc 1 2 *, Angela T. Morgan, PhD 3 4
1Centre for Neuroscience, University of Melbourne, Australia
2Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Melbourne, Australia
3Department of Paediatrics, University of Melbourne, Australia
4Healthy Development Theme, Murdoch Childrens Research Institute, Melbourne, Australia
"No abstract"
Letter to the Editor
Adam P. Vogel, MSc 1 2 *, Angela T. Morgan, PhD 3 4
1Centre for Neuroscience, University of Melbourne, Australia
2Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Melbourne, Australia
3Department of Paediatrics, University of Melbourne, Australia
4Healthy Development Theme, Murdoch Childrens Research Institute, Melbourne, Australia
"No abstract"
PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload
Antioxidants & Redox Signaling. Ahead of print. doi:10.1089/ars.2009.2940.
Zhongbing Lu, Xin Xu, Xinli Hu, John Fassett, Guangshuo Zhu, Yi Tao, Jingxin Li, Yimin Huang, Ping Zhang, Baolu Zhao, Yingjie Chen.
Keywords: Mitochondria, reactive oxygen species (ROS, heart, Peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α), SOD2, and thioredoxin (Trx2), 3’-nitrotyrosine, 4-hydroxynonenal, TAC-induced myocardial oxidative stress, hypertrophy,dysfunction.
Zhongbing Lu, Xin Xu, Xinli Hu, John Fassett, Guangshuo Zhu, Yi Tao, Jingxin Li, Yimin Huang, Ping Zhang, Baolu Zhao, Yingjie Chen.
Keywords: Mitochondria, reactive oxygen species (ROS, heart, Peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α), SOD2, and thioredoxin (Trx2), 3’-nitrotyrosine, 4-hydroxynonenal, TAC-induced myocardial oxidative stress, hypertrophy,dysfunction.
Tuesday, June 29, 2010
Exercise Capacity and Idebenone Intervention in Children and Adolescents With Friedreich Ataxia
Archives of Physical Medicine and Rehabilitation, Vol=91, Issue 7, Pages 1044-1050 (July 2010)
( Presented in part to the American College of Sports Medicine, Seattle, WA, May 28, 2009.)
Drinkard BE, Keyser RE, Paul SM, Arena R, Plehn JF, Yanovski JA, Di Prospero NA.
Keywords: Friedreich's Ataxia (FA), idebenone, randomized double-blind, placebo-controlled, oxidative stress, peak oxygen consumption per unit time (peak VO2), peak work rate (WR), Echocardiography, neurologic assessments, exercise.
( Presented in part to the American College of Sports Medicine, Seattle, WA, May 28, 2009.)
Drinkard BE, Keyser RE, Paul SM, Arena R, Plehn JF, Yanovski JA, Di Prospero NA.
Keywords: Friedreich's Ataxia (FA), idebenone, randomized double-blind, placebo-controlled, oxidative stress, peak oxygen consumption per unit time (peak VO2), peak work rate (WR), Echocardiography, neurologic assessments, exercise.
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