Medical News Today, Article Date: 28 Apr 2010 - 5:00 PDT
In studies on cancer, heart disease, neurological disorders and other degenerative conditions, some scientists are moving away from the "nature versus nurture" debate, and are finding you're not a creature of either genetics or environment, but both - with enormous implications for a new approach to health. read more
Wednesday, April 28, 2010
Molecular Perspective Review of Biochemical Role of Nucleobases Modified by Oxidative Stress
COMPUTATIONAL METHODS IN SCIENCE AND TECHNOLOGY 16(1), XX-XX (2010)
Piotr Cysewski1,2
1 Department of Physical Chemistry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń,
ul. Kurpińskiego 5, 85-950 Bydgoszcz, Poland
2Department of General Chemistry, University of Technology and Life Sciences in Bydgoszcz,
ul. Seminaryjna 3, 85-326 Bydgoszcz, Poland
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"Examples of cancer and non-cancer diseases, for which elevated levels of hydroxyl radical nucleobases were reported [12-15]. : .../... Elevated level in chromatin hydrolysates (GA) in Friedreich' ataxia"
Piotr Cysewski1,2
1 Department of Physical Chemistry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń,
ul. Kurpińskiego 5, 85-950 Bydgoszcz, Poland
2Department of General Chemistry, University of Technology and Life Sciences in Bydgoszcz,
ul. Seminaryjna 3, 85-326 Bydgoszcz, Poland
FULL TEXT PDF
"Examples of cancer and non-cancer diseases, for which elevated levels of hydroxyl radical nucleobases were reported [12-15]. : .../... Elevated level in chromatin hydrolysates (GA) in Friedreich' ataxia"
Tuesday, April 27, 2010
Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation
1Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin, USA.
2Baylor Research Institute, Institute of Metabolic Disease, Dallas, Texas, USA.
3Texas Institute for Genomic Medicine, Houston, Texas, USA.
4Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA.
5Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
6Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
7Department of Biostatistics and
8Department of Anesthesiology, University of Wisconsin, Madison, Wisconsin, USA.
2Baylor Research Institute, Institute of Metabolic Disease, Dallas, Texas, USA.
3Texas Institute for Genomic Medicine, Houston, Texas, USA.
4Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA.
5Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
6Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
7Department of Biostatistics and
8Department of Anesthesiology, University of Wisconsin, Madison, Wisconsin, USA.
Keywords: folate supplementation, neurodegenerative and neuropsychiatric disorders, afferent spinal neurons, DNA methylation, axonal regeneration, epigenetic mechanism contributing to neurorepair, promote regeneration.
See the related Commentary:
J. Clin. Invest. doi:10.1172/JCI40764.
Neuronal injury: folate to the rescue?
Golo Kronenberg, Matthias Endres
Monday, April 26, 2010
Understanding the molecular mechanisms of Friedreich Ataxia to develop therapeutic approaches.
Hum Mol Genet. 2010 Apr 22.
Stéphane Schmuckera,d,e and Hélène Puccioa,b,c,d,e,* a IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), 1 rue Laurent Fries, BP10142, Illkirch, F-67400 France ; b Inserm, U596, Illkirch, F-67400 France ; c CNRS, UMR7104, Illkirch, F-67400 France ; d Université Louis Pasteur, Strasbourg, F-67000, France ; e Collège de France, Chaire de génétique humaine, Illkirch, F-67400 France
Keywords: Friedreich ataxia, neurodegenerative disease, frataxin, iron sulfur cluster (ISC), cellular iron dysregulation, potential novel therapeutic approaches.
Friday, April 23, 2010
[Usefulness of electromyography in diagnostics of the neuro-muscular diseases]
Przegl Lek. 2009;66(11):913-9.
[Article in Polish]
Keywords: Electrophysiological examinations, neuromuscular disorders, monitoring of the disease progress, differential diagnosis.
Kroczka S, Steczkowska M, Kaciński M.
Katedry Neurologii Dzieci i Młodziezy, Uniwersytet Jagielloński Collegium Medicum, Kraków. neupedkr@cm-uj.krakow.pl
[Article in Polish]
Keywords: Electrophysiological examinations, neuromuscular disorders, monitoring of the disease progress, differential diagnosis.
Thursday, April 22, 2010
Novel Strategy For Generating Induced Pluripotent Stem Cells For Clinical Use Is Safe And Efficient
Medical News Today,
Article Date: 17 Apr 2010 - 0:00 PDT
A new technique for reprogramming human adult cells could greatly improve the safety and efficiency of producing patient-specific stem cells for use in a range of therapeutic applications to repair or replace damaged or diseased tissues.
Original paper full text pdf
Article Date: 17 Apr 2010 - 0:00 PDT
A new technique for reprogramming human adult cells could greatly improve the safety and efficiency of producing patient-specific stem cells for use in a range of therapeutic applications to repair or replace damaged or diseased tissues.
Original paper full text pdf
Wednesday, April 21, 2010
Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions.
PLoS Biol. 2010 Apr 13;8(4):e1000354.
Highlight: "Our data support the role of frataxin as an iron donor for IscU to form the Fe-S clusters."
FULL TEXT PDF
1 Department of Biochemistry, McGill University, Montréal, Québec, Canada, 2 Laboratorio de Genética Molecular, Centro de Investigación Príncipe Felipe, Valencia, Spain, 3 Biotechnology Research Institute, Montréal, Québec, Canada
OPEN ACCES
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Tuesday, April 20, 2010
A New Proposal For Achieving Neuronal Regeneration
Medical News Today, Article Date: 20 Apr 2010 - 2:00 PDT
Over the past four years, in the installations of the Faculty of Medicine, University of Cadiz, a group of researchers, headed by Doctor Carmen Estrada, has been studying neurogenesis the process of forming new neurons from mother cells in the adult mammal brain. The purpose of this research project is to contribute to the knowledge of this process with the object of finding some additional mechanism that would facilitate the treatment of pathologies of the central nervous system (CNS) that are suffered in consequence of neuronal death...
Over the past four years, in the installations of the Faculty of Medicine, University of Cadiz, a group of researchers, headed by Doctor Carmen Estrada, has been studying neurogenesis the process of forming new neurons from mother cells in the adult mammal brain. The purpose of this research project is to contribute to the knowledge of this process with the object of finding some additional mechanism that would facilitate the treatment of pathologies of the central nervous system (CNS) that are suffered in consequence of neuronal death...
Frataxin, the mitochondrial iron chaperone for Fe-S cluster bioassembly
ProQuest, Dissertations & Theses
Jeremy David, Ph.D.,Wayne State University, 2010, 256 pages; AAT 3390960
Jeremy David, Ph.D.,Wayne State University, 2010, 256 pages; AAT 3390960
Keywords: Iron, human disorders and diseases, Freidreich's Ataxia (FRDA),
frataxin, mitochondria, iron homeostasis, chaperone, Iron Sulfur Cluster (ISC), ferrous iron, carboxylate ligands
Saturday, April 17, 2010
Erhaltene Reflexe, Propriozeption, SNAPs: trotzdem Friedreich-Ataxie - [Retained reflexes, proprioception, SNAPs: still Friedreich's ataxia]
Nervenarzt. 2010 Apr;81(4):442-3.
DOI: 10.1007/s00115-010-2946-3
Article in German
FULL TEXT PDF
DOI: 10.1007/s00115-010-2946-3
K. Dimitriadis1, 2, S. Heck2, M. Schubert1 und T. Klopstock1, 2
| (1) | Friedrich-Baur-Institut an der Neurologischen Klinik und Poliklinik, Klinikum der Universität München – Innenstadt, Ziemssenstraße 1a, 80336 München |
| (2) | Neurologische Klinik und Poliklinik, Klinikum der Universität München – Großhadern, München |
Article in German
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