Longitudinal tracking of gait and balance impairments in cerebellar disease

Movement Disorders, Published Online: 11 Jun 2010, DOI 10.1002/mds.23169

Sussanne M. Morton, PhD, PT 1, Ya-Weng Tseng, PhD, PT 2, Kathleen M. Zackowski, PhD, OTR 3 4 5, Jaclyn R. Daline, PT, DPT 6, Amy J. Bastian, PhD, PT 3 4 5 *
1Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
2Department of Physical Therapy, Temple University, Philadelphia, Pennsylvania, USA
3Kennedy Krieger Institute, Baltimore, Maryland, USA
4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
5Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
6Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri, USA

Keywords: ICARS,cerebellum, walking, ataxia, clinical assessment, sensitivity

Obstacles to Stem Cell Therapy Cleared

ScienceDaily (June 8, 2010) — Researchers at Lund University have come up with a new technique to prevent tumours developing in connection with stem cell transplantations. read more


Original paper: Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors. R. Sachdeva, M. E. Jonsson, J. Nelander, A. Kirkeby, C. Guibentif, B. Gentner, L. Naldini, A. Bjorklund, M. Parmar, J. Jakobsson. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.1006568107

Erythropoietin Activates Mitochondrial Biogenesis and Couples Red Cell Mass to Mitochondrial Mass in the Heart

Circulation Research. 2010;106:1722, doi: 10.1161/CIRCRESAHA.109.214353

 

Martha S. Carraway, Hagir B. Suliman, W. Schuyler Jones, Chien-Wen Chen, Abdelwahid Babiker, Claude A. Piantadosi
From the Departments of Medicine (Pulmonary [M.S.C., C.-W.C., C.A.P.] and Cardiology [W.S.J.]), Anesthesiology (H.B.S., A.B., C.A.P.), and Pathology (C.A.P.), Duke University Medical Center Durham, NC. Present address for M.S.C.: Environmental Public Health Division, US Environmental Protection Agency, Chapel Hill, NC. Present address for C.-W.C.: Division of Chest Medicine, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan. Present address for A.B.: Department of Virology and Immunology, Faculty of Medicine, King Khalid University, Abha, Saudi Arabia.

A Closer Look at Stem Cell Treatments

The International Society for Stem Cell Research (ISSCR)  has launched this new Web site "A Closer Look at Stem Cell Treatments", it's aimed to patients, their families and doctors,  it contains information that can be very useful to make decisions about the new promising stem cell treatments. The ISSCR urges individuals to be cautious and to learn the facts before making any decision.


"Una mirada cercana a los tratamientos con células madre",
La Sociedad Internacional para la Investigación con Células Madre (ISSCR) ha puesto en marcha este nuevo sitio Web "Una mirada cercana a los tratamientos con células madre", está dirigida a los pacientes, sus familias y los médicos, contiene información que puede ser muy útil para tomar decisiones acerca de los nuevos y prometedores tratamientos con células madre. La ISSCR insta a tener cuidado y estudiar los detalles antes de tomar cualquier decisión.

Treatment of neurological scoliosis of more than 1008 by using a hybrid contstruct (pedicle screws plus universal clamps)

La Rosa G, Giglio G, Oggiano L.
Treatment of neurological scoliosis of more than 1008 by using a hybrid contstruct (pedicle screws plus universal clamps). Paper #F484. To be presented at the EFORT Congress 2010. June 2-5, 2010. Madrid.

Hybrid construct provides adequate correction of deformity in patients with neurological scoliosi. 
Italian orthopaedists reported a low rate of complications when treating patients with high-grade neurological scoliosis using a hybrid construct that combined lumbar pedicle screws, Universal Clamps (Zimmer) and thoracic hooks...... read more

Frataxin and mitochondrial Fe-S cluster biogenesis.

The Journal of biological chemistry (3 June 2010)

Timothy L. Stemmler1, Emmanuel Lesuisse2, Debkumar Pain3, Andrew Dancis4.

Wayne State University School of Medicine, United States; CNRS-Universite Paris Diderot, France; UMDNJ, New Jersey Medical School, United States; 4 University of Pennsylvania, United States

Keyword: Friedreich's ataxia, neurodegenerative disease, frataxin, mitochondrial protein, Fe-S cluster, Isu, iron, cysteine desulfurase Nfs1.

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Breakthrough In Stem Cell Culturing

Medical News Today, Article Date: 02 Jun 2010
For the first time, human embryonic stem cells have been cultured under chemically controlled conditions without the use of animal substances, which is essential for future clinical uses. The method has been developed by researchers at Karolinska Institutet and is presented in the journal Nature Biotechnology.  read more

Immune System Helps Transplanted Stem Cells Navigate in Central Nervous System

ScienceDaily (June 1, 2010) — By discovering how adult neural stem cells navigate to injury sites in the central nervous system, UC Irvine researchers have helped solve a puzzle in the creation of stem cell-based treatments: How do these cells know where to go?

Projets de traitement des maladies d’Alzheimer et de Friedreich

Very encouraging news, Dr. Patrick Aubourg, will work with FA, this Dr. has already succeeded in stopping the evolution of Adrenoleukodystrophy(ALD), also called "Siemerling-Creutzfeldt Disease in some children, with autologous trasplant of bone marrow stem cells, with cells corrected by gene therapy

Patrick Aubourg,  Docteur en médecine et Professeur à l’Université Paris-Descartes. Il dirige l'Unité Inserm Génétique et biothérapies des maladies dégénératives et prolifératives du système nerveux, à l’Hôpital Saint-Vincent de Paul.

Le Grand Prix scientifique 2010 de la Fondation Simone et Cino del Duca a été attribué au Professeur Patrick Aubourg.

Dans l’ataxie de Friedreich, l’objectif est d’introduire le gène fonctionnel de la frataxine, une protéine essentielle au fonctionnement du cervelet, localisée dans des organites cellulaires précis : les mitochondries. Le manque de frataxine dans ces organites entraîne la perturbation d'une structure indispensable à leur bon fonctionnement, et tardivement une accumulation de fer. L’équipe de Patrick Aubourg teste deux nouveaux vecteurs viraux de thérapie génique pour déterminer lequel, après injection intra-veineuse, a la plus grande efficacité pour faire exprimer la frataxine non seulement dans les cellules du cervelet, mais aussi dans le cœur et la moelle épinière.

PRESS RELEASE IN ENGLISH 

More information about ADL Treatment:

Successful treatment of adrenoleukodystrophy by transplantation of ..

2 Children Suffering From Adrenoleukodystrophy Saved Thanks To The ELA Association

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy
Science 6 November 2009: Vol. 326. no. 5954, pp. 818 - 823, DOI: 10.1126/science.1171242

Astrocyte-Specific Overexpression of Nrf2 Protects Striatal Neurons from Mitochondrial Complex II Inhibition

Toxicol Sci. 2010 Jun;115(2):557-68. Epub 2010 Mar 8.

Calkins MJ, Vargas MR, Johnson DA, Johnson JA.

Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA.