Frataxin depletion in yeast triggers upregulation of iron transport systems before affecting iron-sulfur enzyme activities.

J Biol Chem. 2010 Oct 18. [Epub ahead of print]
Moreno-Cermeno A, Obis E, Belli G, Cabiscol E, Ros J, Tamarit J.

University of Lleida, Spain.

Keywords: frataxin, a mitochondrial protein, iron homeostasis, yeast model, frataxin homolog YFH1, aconitase, secondary events, iron overloading, superoxide dismutase, protein carbonyl formation, manganese, metal ion transporter Smf2.

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