Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons

Genome Res. Published in Advance April 5, 2011, doi: 10.1101/gr.112755.110

Kazuya Iwamoto 1,2,7,8, Miki Bundo 1,2,7, Junko Ueda 1, Michael C. Oldham 3, Wataru Ukai 4, Eri Hashimoto 4, Toshikazu Saito 4, Daniel H. Geschwind 5,6 and Tadafumi Kato 1,8

1 Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Japan; 2Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo 7-3-1 Hongo, Japan; 3 Department of Neurology, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, USA; 4 Department of Neuropsychiatry, Sapporo Medical University, Japan;
5 Program in Neurogenetics, Department of Neurology, and the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, USA; 6 Department of Human Genetics, University of California, USA

Keywords: Epigenome, mammalian brain cells, DNA methylation, hypomethylation, transcription-factor binding sites, central nervous system.