Therapeutic potential of stem cells for treatment of neurodegenerative diseases

Ahmadian-Moghadam, H., Sadat-Shirazi, M. & Zarrindast, M.; Biotechnol Lett (2020). doi:10.1007/s10529-020-02886-1

The regenerative potential of stem cells drew the attention of researchers to cell-based therapy for treating neurodegenerative diseases. The clinical application of stem cells may help to substitute new cells and overcome the inability of the endogenous repairing system to repair the damaged brain. However, the clinical application induced pluripotent stem cells are restricted due to the risk of tumor formation by residual undifferentiated upon transplantation. In this focused review, we briefly discussed different stem cells currently being studied for therapeutic development. Moreover, we present supporting evidence for the utilization of stem cell therapy for the treatment of neurodegenerative diseases.

Therapeutic potential of stem cells for treatment of neurodegenerative diseases