We show that an episode of synaptic activity increases mitochondrial bioenergetics beyond the duration of the synaptic activity by transcriptionally inducing the expression of iron metabolism genes with the consequent enhancement of cellular and mitochondrial iron uptake. Iron is a necessary component of the electron transport chain complexes, and its chelation or knockdown of mitochondrial iron transporter Mfrn1 blocks the activity-mediated bioenergetics boost. We found that Mfrn1 expression is regulated by the well-known regulator of synaptic plasticity CREB, suggesting the coordinated expression of synaptic plasticity programs with those required to meet the associated increase in energetic demands
Tuesday, February 7, 2023
Synaptic activity regulates mitochondrial iron metabolism to enhance neuronal bioenergetics
Tena-Morraja, P., Riqué-Pujol, G., Müller-Sánchez, C., Reina, M., Martínez-Estrada, O. M., & Soriano, F. X. (2023). Synaptic activity regulates mitochondrial iron metabolism to enhance neuronal bioenergetics. International Journal of Molecular Sciences, 24(2), 922. doi:10.3390/ijms24020922
