Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors

http://www.nature.com/gt/journal/vaop/ncurrent/abs/gt2008186a.html
Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors
A Rahim1,2,3, A M S Wong4, S J Howe2, S M K Buckley3, A D Acosta-Saltos1, K E Elston4, N J Ward2, N J Philpott2, J D Cooper4, P N Anderson5, S N Waddington3, A J Thrasher2,6 and G Raivich1,5
1Perinatal Brain Protection and Repair Group, Department of Obstetrics and Gynaecology, University College London, London, UK
2Molecular Immunology Unit, Centre for Immunodeficiency, Institute of Child Health, University College London, London, UK
3Department of Haematology, Haemophilia Centre and Haemostasis Unit, Royal Free and University College Medical School, London, UK
4Pediatric Storage Disorders Laboratory, Department of Neuroscience, Institute of Psychiatry, Kings College London, London, UK
5Department of Anatomy and Developmental Biology, University College London, London, UK
6Great Ormond Street Hospital NHS Trust, London, UK
Correspondence: Dr AJ Thrasher, Molecular Immunology Unit, Centre for Immunodeficiency, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. E-mail: a.thrasher@ich.ucl.ac.uk
Received 12 June 2008; Revised 2 December 2008; Accepted 3 December 2008; Published online 22 January 2009.