Neuronal loss/dysfunction was indicated in the cerebellar vermis and hemispheres in both diseases by lower total N-acetylaspartate levels than controls. The putative gliosis marker myo-inositol was higher than controls in the vermis and pons in AOA2 and in the vermis in FRDA. Total creatine, another potential gliosis marker, was higher in the cerebellar hemispheres in FRDA relative to controls. Higher glutamine in FRDA and lower glutamate in AOA2 than controls were observed in the vermis, indicating different mechanisms possibly leading to altered glutamatergic neurotransmission. In AOA2, total N-acetylaspartate levels in the cerebellum strongly correlated with the FARS score (p < 0.01).
Monday, October 19, 2026
1H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2
sabelle Iltis, Diane Hutter, Khalaf O. Bushara, H. Brent Clark, Myron Gross, Lynn E. Eberly, Christopher M. Gomez, Gülin Öz, 1H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2, Brain Research, Volume 1358, 2010, Pages 200-210, ISSN 0006-8993, doi:10.1016/j.brainres.2010.08.030.
