Out of 2035 genes, 1260 were upregulated and 775 downregulated. FBgn0000261 (Catalase) and FBgn0024958 (Irp1A) were significantly down in fh-/- mutants, while FBgn0039561 (mitoferrin) was significantly up.GO enrichment highlighted proteolysis as the top biological process, followed by small molecule metabolism and transmembrane transport. KEGG and REACTOME analyses confirmed enrichment in oxidative phosphorylation, metabolic pathways, and immune processes (FDR<0.001). These defects reveal mitochondrial dysfunction and oxidative stress in the disease model.
Monday, October 19, 2026
Transcriptomic Profiling of Frataxin-Deficient Drosophila melanogaster to Identify Molecular Drivers and Pathway Disruptions in Friedreich’s Ataxia
V. Swarup, R. Yadav, A. Ahuja, P. Yadav, A. Srivastava, D. Garg. Transcriptomic Profiling of Frataxin-Deficient Drosophila melanogaster to Identify Molecular Drivers and Pathway Disruptions in Friedreich’s Ataxia [abstract]. Mov Disord. 2026; 41 (suppl 1). October 19, 2026.
