Cytokine analyses demonstrated alterations in circulating inflammatory and remodeling markers; however, predictive modeling indicated that these alone had limited discriminatory performance. Model accuracy improved when variables were integrated with clinical and imaging metrics, suggesting a subset of circulating proteins contributes to disease pathways. Lipidomic profiling revealed distinct remodeling of inflammatory lipid mediator pathways, with clear separation between FA and control driven by coordinated pathway-level changes. Mass spec proteomics and early single-cell immune profiling further identified trends consistent with mitochondrial stress, immune activation, and fibro-inflammatory signaling.
Monday, October 19, 2026
Multi-Omics Biomarker Discovery in Friedreich’s Ataxia Cardiomyopathy
F. Siddiqui, T. Keller, C. Koehring, G. Upadhyay, B. Higgins, T. Zesiewicz, K. Kim, G. Halade, A. Patel, T. Mcdonald. Multi-Omics Biomarker Discovery in Friedreich’s Ataxia Cardiomyopathy [abstract]. Mov Disord. 2026; 41 (suppl 1). https://www.mdsabstracts.org/abstract/multi-omics-biomarker-discovery-in-friedreichs-ataxia-cardiomyopathy/. Accessed October 19, 2026.
