Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain

Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain. Stephen F.J. McGovern, Kerry Hunter, Christian Hölscher, Brain Research, Volume 1473, 14 September 2012, Pages 204-213. http://dx.doi.org/10.1016/j.brainres.2012.07.029.

Keywords: Insulin, Incretin, Neurodegenerative disease, Alzheimer's disease, Cognition, Diabetes, Neurogenesis.

The results demonstrate that (Val8)GLP-1 is safe in a range of doses, crosses the BBB and has potentially beneficial effects in the CNS by enhancing neurogenesis.


Fármaco antidiabético contra las enfermedades neurodegenerativas

An Objective Double-blind Evaluation of Bupropion and Citalopram in an Individual With Friedreich Ataxia

An Objective Double-blind Evaluation of Bupropion and Citalopram in an Individual With Friedreich Ataxia.

The purpose of this study is to document the clinical effects of bupropion and citalopram in a single subject with Friedreich Ataxia.(Phase 4)

ClinicalTrials.gov
Identifier: NCT01716221
First received: October 25, 2012

Sponsor: University of Colorado, Denver
Information provided by (Responsible Party): University of Colorado, Denver

Microsatellites as targets of natural selection.

Microsatellites as targets of natural selection. Haasl RJ, Payseur BA.; Mol Biol Evol. 2012 Oct 27.

Keywords: polymorphism, natural selection, mutation, multiallelic loci, microsatellites, microsatellite mutation, Friedreich's ataxia.

Lesser Toe Deformities – Pathogenesis and Practice-Oriented Nomenclature

Lesser Toe Deformities – Pathogenesis and Practice-Oriented Nomenclature. Deformitäten der Kleinzehen – Pathogenese und praxisnahe Nomenklatur. Veronika Redkina, Alexander Sikorski, Johannes Beike; Fuß & Sprunggelenk, Available online 29 October 2012. http://dx.doi.org/10.1016/j.fuspru.2012.10.001

Published in German

Characterising the Neuropathology and Neurobehavioural Phenotype in Friedreich Ataxia: A Systematic Review

Characterising the Neuropathology and Neurobehavioural Phenotype in Friedreich Ataxia: A Systematic Review. Louise A. Corben, Nellie Georgiou‑Karistianis, John L. Bradshaw, Marguerite V. Evans‑Galea, Andrew J. Churchyard and Martin B. Delatycki;
From the book Tandem Repeat Polymorphisms: Genetic Plasticity, Neural Diversity and Disease, Edited by: Anthony J. Hannan, ISBN: 978-1-4614-5433-5, Publication date: October 26, 2012

Neuroanatomical Correlates of Depression in Friedreich's Ataxia: a Voxel-Based Morphometry Study.

Neuroanatomical Correlates of Depression in Friedreich's Ataxia: a Voxel-Based Morphometry Study. da Silva CB, Yasuda CL, D'Abreu A, Cendes F, Lopes-Cendes I, França MC Jr.; Cerebellum. 2012 Oct 24.

Keywords: Affective disorders, neurodegenerative diseases, poor quality of life, depression, Beck Depression Inventory, cerebral 3 T MRI scans, structural abnormalities, white matter, reduction of gray matter volumes.

Letter by Peverill Regarding Article, “The Heart in Friedreich Ataxia: Definition of Cardiomyopathy, Disease Severity, and Correlation With Neurological Symptoms”

Letter by Peverill Regarding Article, “The Heart in Friedreich Ataxia: Definition of Cardiomyopathy, Disease Severity, and Correlation With Neurological Symptoms” , Roger E. Peverill, MB, BS, PhD; Circulation. 2012; 126: e272 doi: 10.1161/CIRCULATIONAHA.112.115287

Keywords: Friedreich ataxia (FA), cardiac disease, premature mortality, cardiomyopathy in FA, left ventricular (LV) mass, interventricular septal thickness.

R- and S-Equol have equivalent cytoprotective effects in Friedreich's Ataxia

R- and S-Equol have equivalent cytoprotective effects in Friedreich's Ataxia, Timothy E Richardson and James W Simpkins, BMC Pharmacology and Toxicology 2012, doi:10.1186/2050-6511-13-12. Published: 22 October 2012

OPEN ACCESS

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These preliminary data demonstrate that estrogen and soy-derived equols could have a beneficial effect in delaying the onset and decreasing the severity of symptoms in FRDA patients by an antioxidant mechanism. In addition, these data confirm that the protection seen previously with E2 was indeed unrelated to ER binding.

Novel Therapeutic Challenges in Cerebellar Diseases

Novel Therapeutic Challenges in Cerebellar Diseases. Antoni Matilla Dueñas, Carme Serrano, Yerko Ivanovic, Ramiro Alvarez, Pilar Latorre, and David Genıs. Documentos RIBERMOV (19/10/2012)

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New Project: Developing bone marrow transplant and novel therapeutic vectors to treat Friedreich ataxia

New Project: Developing bone marrow transplant and novel therapeutic vectors to treat Friedreich ataxia.  Professor Martin Delatycki.  Federal Government's National Health and Medical Research Council (NHMRC) funding (Australia).