Fe-S cluster biogenesis in isolated mammalian mitochondria: coordinated use of persulfide sulfur and iron, and requirements for GTP, NADH, and ATP

Fe-S cluster biogenesis in isolated mammalian mitochondria: coordinated use of persulfide sulfur and iron, and requirements for GTP, NADH, and ATP . Alok Pandey, Jayashree Pain, Arnab K. Ghosh, Andrew Dancis and Debkumar Pain; J. Biol. Chem. jbc.M114.610402. First Published on November 14, 2014, doi:10.1074/jbc.M114.610402

The experimental system as described here may help to define the biochemical basis of diseases that are associated with impaired Fe-S cluster biogenesis in mitochondria such as Friedreich's ataxia.

Mechanism Involved in the Blunted Anti-Oxidant Response in the Frataxin-Deficient Heart: Increased Nrf2 Degradation via both the Keap1 and GSK3β Pathway

Mechanism Involved in the Blunted Anti-Oxidant Response in the Frataxin-Deficient Heart: Increased Nrf2 Degradation via both the Keap1 and GSK3β Pathway. Amy Anzovino, Clare L. Hawkins, Michael L.H. Huang, Des R. Richardson; Free Radical Biology and Medicine, Volume 76, Supplement 1, November 2014, Page S46, ISSN 0891-5849, http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.402.

Transforming Our Approach to Translational Neuroscience: The Role and Impact of Charitable Nonprofits in Research

Transforming Our Approach to Translational Neuroscience: The Role and Impact of Charitable Nonprofits in Research. Cynthia Joyce, Neuron, Volume 84, Issue 3, 5 November 2014, Pages 526-532, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2014.10.030.

Friedreich Ataxia

Friedreich Ataxia. Massimo Pandolfo; Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease (Fifth Edition). 2015, Pages 833–843

Keywords: Ataxia; Cardiomyopathy; Chromatin; Histone acetylation; Induced pluripotent stem cells; Iron–sulfur clusters; Mitochondria, Iron; Neurodegenerative diseases; Oxidative stress; Transgenic mice; Triplet repeat expansion

NEW TOOL: ClinRegs, an online database of country-specific clinical research regulatory information

NEW: ClinRegs, an online database of country-specific clinical research regulatory information . The National Institutes of Health (NIH)

ClinRegs is an online database of country-specific clinical research regulatory information designed to save time and effort in planning and implementing clinical research.

When Lives Depend on Tech Transfer

When Lives Depend on Tech Transfer . IPWatchdog.com, Written by Joseph Allen, Allen & Associates.
Posted: Nov 3, 2014

Malfunctioning of the Iron–Sulfur Cluster Assembly Machinery in Saccharomyces cerevisiae Produces Oxidative Stress via an Iron-Dependent Mechanism, Causing Dysfunction in Respiratory Complexes

Malfunctioning of the Iron–Sulfur Cluster Assembly Machinery in Saccharomyces cerevisiae Produces Oxidative Stress via an Iron-Dependent Mechanism, Causing Dysfunction in Respiratory Complexes. Mauricio Gomez, Rocío V. Pérez-Gallardo, Luis A. Sánchez, Alma L. Díaz-Pérez, Christian Cortés-Rojo, Victor Meza Carmen, Alfredo Saavedra-Molina, Javier Lara-Romero, Sergio Jiménez-Sandoval, Francisco Rodríguez, José S. Rodríguez-Zavala, Jesús Campos-García. (2014)PLoS ONE 9(10): e111585. doi:10.1371/journal.pone.0111585

Charities’ role in supporting medical research

Charities’ role in supporting medical research. Times Higher Education, 16 October 2014

A group of medical charities spent more on health research last year than two government funding bodies, according to a report

Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery

Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery. Diego Brancaccio, Angelo Gallo, Maciej Mikolajczyk, Kairit Zovo, Peep Palumaa, Ettore Novellino, Mario Piccioli, Simone Ciofi-Baffoni, and Lucia Banci; Journal of the American Chemical Society Just Accepted Manuscript DOI: 10.1021/ja507822j

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes. Vogel AP, Folker J, Poole ML; Cochrane Database of Systematic Reviews 2014, Issue 10. Art. No.: CD008953. DOI: 10.1002/14651858.CD008953.pub2

Review about the evidence about the effects of treatment on speech difficulties in people with Friedreich ataxia and other hereditary ataxias.