Cerebellar Contributions to Adaptive Control of Saccades in Humans

The Journal of Neuroscience, October 14, 2009, 29(41):12930-12939; doi:10.1523/JNEUROSCI.3115-09.2009

Minnan Xu-Wilson,1 Haiyin Chen-Harris,1 David S. Zee,2 and Reza Shadmehr1

1Departments of Biomedical Engineering and 2Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205

Keywords: cerebellum, internal feedback correct, saccades, cerebellar damage, dysmetria.

Nutrition, Brain Aging, and Neurodegeneration

The Journal of Neuroscience, October 14, 2009, 29(41):12795-12801; doi:10.1523/JNEUROSCI.3520-09.2009

James Joseph,1 Greg Cole,2 Elizabeth Head,3 and Donald Ingram4

1USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, 2Geriatric Research, Education and Clinical Centers, Veterans Affairs Medical Center, and Department of Medicine, University of California, Los Angeles, Sepulveda, California 91343, 3University of Kentucky Sanders-Brown Center on Aging, Lexington, Kentucky 40536, and 4Pennington Biomedical Center, Baton Rouge, Louisiana 70808



Unfortunately we all know what is the FA, and these tips are not enough, but they are interesting.

Long-Term Safety and Tolerability of Idebenone in Friedreich's Ataxia Patients (MICONOS Extension)

Official Title: A Phase III Open-Label, Single-Group, Extension Study to Obtain Long-Term Safety and Tolerability Data of Idebenone in the Treatment of Friedreich's Ataxia Patients.

This study is currently recruiting participants.
Verified by Santhera Pharmaceuticals, October 2009
First Received: October 13, 2009

Sponsored by: Santhera Pharmaceuticals

ClinicalTrials.gov Identifier: NCT00993967

Stress ossidativo ed anomalie citoscheletriche nell’Atassia di Friedreich

Piemonte, Fiorella
Gaeta, Laura Maria
UNIVERSITÀ DEGLI STUDI DI ROMA "TOR VERGATA", FACOLTA' DI MEDICINA, DOTTORATO DI RICERCA IN BIOTECNOLOGIE MEDICHE E MEDICINA MOLECOLARE

Issue Date: 6-Aug-2009

Keywords: Atassia di Friedreich, glutatione, proteine glutationilate, citoscheletro, stress ossidativo, regolazione redox.

Link to full text: http://dspace.uniroma2.it/dspace/bitstream/2108/994/1/TESI+DI+DOTTORATO.pdf

A comparison of three measures of upper limb function in Friedreich ataxia.

J Neurol. 2009 Oct 13.
Corben LA, Tai G, Wilson C, Collins V, Churchyard AJ, Delatycki MB.
Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Flemington Rd, Parkville, VIC, 3052, Australia.

Keywords: Friedreich Ataxia (FRDA), false negative results, upper limb function, the Nine Hole Peg Test (9HPT), Box and Blocks Test (BBT), Jebsen Taylor Hand Function Test (JTHFT),Friedreich Ataxia Functional Composite (FAFC) test, clinical studies, terapeutic trials, age at disease onset, disease duration, Friedreich Ataxia Rating Scale (FARS).

Antioxidants and other pharmacological treatments for Friedreich ataxia.

Cochrane Database Syst Rev. 2009 Oct 7;4:CD007791

Kearney M, Orrell RW, Fahey M, Pandolfo M.
General Practice, Irish College of General Practitioners, Dunlavin, County Wicklow, Ireland.

Keywords: Friedreich ataxia, autosomal recessive, neurological disorder, slurred speech, scoliosis, pes cavus, heart abnormalities, antioxidants, controlled trials, international Co-operative Ataxia Rating Scale (ICARS),left ventricular heart mass, magnetic resonance imaging, echocardiography, idebenone.

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Rao Muralikrishna Adibhatla, James Franklin Hatcher, Savita Khanna, Shrinivas K. Kulkarni, Pamela Maher, Cesare Mancuso, Stanley I. Rapoport, Mark Smith, Bobby Thomas, Tatsurou Yagami. Antioxidants & Redox Signaling. -Not available-, ahead of print. doi:10.1089/ars.2009.2668.

Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. William S. Middleton Veterans Affairs Hospital, Madison, Wisconsin.

Keywords: Reactive oxygen species (ROS), oxidative phosphorylation, NAD(P)H oxidases, arachidonic acid oxidative metabolism, endogenous antioxidant defenses, Nrf2/ARE, Oxidative stress, lipids, cell death, oxidized phospholipids, 4-hydroxynonenal, 4-oxo-2-nonenal, acrolein, neurodegenerative diseases (AD, ALS, bipolar disorder, epilepsy, Friedreich's ataxia, HD, MS, NBIA, NPC, PD, peroxisomal disorders, schizophrenia, Wallerian degeneration, Zellweger syndrome), CNS traumas (stroke, TBI, SCI), free iron, Fenton reaction, cholesterol, lipid oxidation/peroxidation.

Risk/Benefit assessment, advantages over other drugs and targeting methods in the use of deferiprone as a pharmaceutical antioxidant in iron loading and non iron loading conditions.

Hemoglobin. 2009;33(5):386-97.

Kontoghiorghes GJ, Efstathiou A, Kleanthous M, Michaelides Y, Kolnagou A.

Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus.

Keywords: oxidative stress, brain, heart, liver, kidneys, classical antioxidants, deferiprone, mobilizing labile iron and copper, free radicals, high therapeutic index, tissue penetration, rapid iron binding, clearance, iron complex, toxicity, cardiomyopathy, thalassemia, diabetic nephropathy, glomerulonephritis, kidney disease, Friedreich's Ataxia, Fanconi Anemia, deferoxamine (DFO), deferasirox (DFRA).

Friedreich ataxia: a computational dynamic model of the key proteins involved in the yeast Fe–S cluster biogenesis

Friedreich ataxia: a computational dynamic model of the key proteins involved in the yeast Fe–S cluster biogenesis
New Biotechnology
Volume 25, Supplement 1, September 2009, Pages S342-S343
Abstracts of the 14th European Congress on BiotechnologyBarcelona, Spain 13–16 September, 2009

I. Amela1, J. Cedano1, P. Delicado2 and E. Querol1

1Universitat Autònoma de Barcelona, Bellatera - Barcelona, Spain

2Universitat Politècnica de Catalunya, Barcelona, Spain

Characterizing gait, locomotor status, and disease severity in children and adolescents with friedreich ataxia.

J Neurol Phys Ther. 2009 Sep;33(3):144-9.

Croarkin E, Maring J, Pfalzer L, Harris-Love M, Siegel K, Diprospero N.
National Institutes of Health (E.C., K.S.), Bethesda, MD; George Washington University, Physical Therapy Program (J.M., M.H.L.), Washington, DC; University of Michigan School of Health Related Professions and Studies (L.P.), Ann Arbor, Michigan; and National Institute of Neurological Disorders and Stroke (N.D.P.), Bethesda, Maryland.

KEYWORDS: gait parameters, children, adolescents, Friedreich ataxia (FA), disease severity, Friedreich Ataxia Rating Scale (FARS), walk.