Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.

Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.


Plecitá-Hlavatá L, Jezek J, Jezek P. Department No 75, Institute of Physiology, Academy of Sciences, Vídenská 1083, Prague, Czech Republic. plecita@...

Source: Int J Biochem Cell Biol. 2009 Aug-Sep;41(8-9):1697-707. Epub 2009 Mar 3.
Link to this abstract: http://www.ncbi.nlm.nih.gov/pubmed/19433311

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

Nature Cell Biology Published online: 17 May 2009 doi:10.1038/ncb1881

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

Angel Herrero-Mendez1, Angeles Almeida1,2, Emilio Fernández1, Carolina Maestre1,2, Salvador Moncada3 & Juan P. Bolaños1

Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Instituto de Neurociencias de Castilla y Leon, 37007 Salamanca, Spain.
Unidad de Investigacion, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Leon, 37007 Salamanca, Spain.
Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
Correspondence to: Juan P. Bolaños1 e-mail: jbolanos@usal.es
Correspondence to: Salvador Moncada3 e-mail: s.moncada@ucl.ac.uk

Autosomal recessive cerebellar ataxias.

Presse Med. 2009 May 11. [Epub ahead of print]

Autosomal recessive cerebellar ataxias.

[Article in French]
Tranchant C, Anheim M.
Clinique neurologique, Hôpitaux universitaires, F-67091 Strasbourg Cedex, France.

Epidemiological, clinical, paraclinical and molecular study of a cohort of 102 patients affected with autosomal recessive progressive cerebellar ataxi

Neurogenetics. 2009 May 14. [Epub ahead of print]

Epidemiological, clinical, paraclinical and molecular study of a cohort of 102 patients affected with autosomal recessive progressive cerebellar ataxia from Alsace, Eastern France: implications for clinical management.
Anheim M, Fleury M, Monga B, Laugel V, Chaigne D, Rodier G, Ginglinger E, Boulay C, Courtois S, Drouot N, Fritsch M, Delaunoy JP, Stoppa-Lyonnet D, Tranchant C, Koenig M.
Département de Neurologie, Hôpital Civil, Centre Hospitalier Universitaire de Strasbourg, 1, place de l'Hôpital, 67000, Strasbourg, France, anheim@titus.u-strasbg.fr.

The biology of PGC-1α and its therapeutic potential

The biology of PGC-1α and its therapeutic potential


Christoph Handschina, b,
aBiozentrum, University of Basel, Klingelbergstrasse 50-70, CH-4056 Basel, Switzerland
bInstitute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Available online 14 May 2009.

Ataxia de Friedreich- Friedreich's ataxia (en la atención primaria)

Aten Primaria. 2009 May 7.
Ataxia de Friedreich- Friedreich's ataxia.

[Article in Spanish]

Ortiz Uriarte R, García Ribes M, Gutiérrez VM, Sorlí JV, Valderrama Zurián FJ, Mingarro Castillo MM, Ejarque Domènech I.Grupo de trabajo semFYC Genética clínica y enfermedades raras; Centro de Salud, La Cavada, Cantabria, España.PMID: 19427070 [PubMed - as supplied by publisher]

A Study Investigating the Long-Term Safety and Efficacy of Deferiprone in Patients With Friedreich's Ataxia

A Study Investigating the Long-Term Safety and Efficacy of Deferiprone in Patients With Friedreich's Ataxia

http://www.clinicaltrials.gov/ct2/show/NCT00897221?term=friedreich

This study is not yet open for participant recruitment.
Verified by ApoPharma, May 2009
First Received: May 8, 2009 No Changes Posted
Sponsored by: ApoPharma

Information provided by: ApoPharma
ClinicalTrials.gov Identifier: NCT00897221

Practical guide to neurogenetics

http://www.thelancet.com/journals/laneur/article/PIIS147444220970122X/fulltext?rss=yes Practical guide to neurogenetics


Practical Guide to Neurogenetics
Thomas Warner, Simon HammansElsevier Saunders, 2008Pp 344. $65·95. ISBN-978-0750654104

Exercise, PGC-1α, and metabolic adaptation in skeletal muscle

Appl. Physiol. Nutr. Metab. 34(3): 424–427 (2009) doi:10.1139/H09-030 Published by NRC Research Press / Publié par les Presses scientifiques du CNRC

Full text: http://article.pubs.nrc-cnrc.gc.ca/RPAS/rpv?hm=HInit&journal=apnm&volume=34&calyLang=eng&afpf=h09-030.pdf

Exercise, PGC-1α, and metabolic adaptation in skeletal muscle

Zhen Yan

Endurance exercise is protective for mice with mitochondrial myopathy

J Appl Physiol 106: 1712-1719, 2009. First published March 12, 2009; doi:10.1152/japplphysiol.91571.2008 8750-7587/09 $8.00

HIGHLIGHTED TOPIC Regulation of Protein Metabolism in Exercise and Recovery

Endurance exercise is protective for mice with mitochondrial myopathy

Tina Wenz,1 Francisca Diaz,1 Dayami Hernandez,1 and Carlos T. Moraes1,2
Departments of 1Neurology and of 2Cell Biology and Anatomy, University of Miami School of Medicine, Miami, Florida
Submitted 8 December 2008 ; accepted in final form 9 March 2009

Address for reprint requests and other correspondence: C. T. Moraes, Dept. of Neurology, Miller School of Medicine, Univ. of Miami, 1095 NW 14th Terrace, Miami, FL 33136 (e-mail: cmoraes@med.miami.edu