Superando la barrera hematoencefálica

Traduccion de EurekAlert!.org, 13 septiembre 2011, que se encuentra en Bitnavegantes


"Por primera vez, los investigadores descubrieron que, cuando los receptores de adenosina se activan en las células que forman la barrera hematoencefálica, se abre una puerta de entrada a través dicha barrera."

Breaching the blood-brain barrier

EurekAlert!, Public release date: 13-Sep-2011

"For the first time, the researchers discovered that when adenosine receptors are activated on cells that comprise the blood-brain barrier, a gateway into the blood-brain barrier can be established."

Adenosine Receptor Signaling Modulates Permeability of the Blood–Brain Barrier

The Journal of Neuroscience, 14 September 2011, 31(37): 13272-13280; doi: 10.1523/​JNEUROSCI.3337-11.2011

Aaron J. Carman, Jeffrey H. Mills, Antje Krenz, Do-Geun Kim, and Margaret S. Bynoe
Department of Microbiology and Immunology, Cornell University, College of Veterinary Medicine, Ithaca, New York 14853

Acute myocardial infarction after botulinum toxin injection.

QJM (2011) 104(7): 615-616

B.E. Stähli, L. Altwegg, T.F. Lüscher and R. Corti
Department of Cardiology, Cardiovascular Center, University Hospital Zürich, Zürich, Switzerland

Keywords: Friedreich ataxia, ventricular fibrillation, botulinum toxin A, neurogenic bladder dysfunction,thrombotic occlusion.

Shuttle-Mediated Drug Delivery to the Brain.

Angew Chem Int Ed Engl. 2011 Jun 30. doi: 10.1002/anie.201006565. [Epub ahead of print]

Malakoutikhah M, Teixidó M, Giralt E.

Institute for Research in Biomedicine (IRB Barcelona), Barcelona (Spain)

Keywords: shuttle-mediated drug delivery, blood-brain barrier (BBB), central nervous system, vector-mediated approach, ability to cross the BBB.

Mesenchymal stem cells: from experiment to clinic

Fibrogenesis & Tissue Repair 2011, 4:20 doi:10.1186/1755-1536-4-20
William R Otto1 and Nicholas A Wright2

1 Histopathology Laboratory, Cancer Research UK, London Research Institute, London, UK. 2 Blizard Institute, Barts and The London, Queen Mary’s School of Medicine and Dentistry, London, UK.

"Good review, defines the current state of research and use of Mesenchymal stem cells"

Importance of Iron Chelation in Free Radical-Induced Oxidative Stress and Human Disease.

Curr Pharm Des. 2011 Sep 9,

Jomova K, Valko M.
Faculty of Chemical and Food Technology, Slovak Technical University, Bratislava, Slovakia.

Keywords: Iron, redox active metal, hemochromatosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, Friedreich's ataxia, neurological disorders, cancer, Fanconi anemia, stroke, ageing, Fenton reaction, reactive oxygen species (ROS), iron-designed chelators.

A listing of clinical trials currently looking for volunteers to enroll in Friedreich's Ataxia studies.

Austria, Innsbruck :

Patient Reported Outcomes in Friedreich's Ataxia Patients After Withdrawal From Treatment With Idebenone (PROTI)

Roles of Porphyrin and Iron Metabolisms in the δ-Aminolevulinic Acid (ALA)-induced Accumulation of Protoporphyrin and Photodamage of Tumor Cells

Photochemistry and Photobiology, Volume 87, Issue 5, pages 1138–1145, September/October 2011, DOI: 10.1111/j.1751-1097.2011.00950.x

Yoshiko Ohgari, Yoshinobu Miyata, Taeko Miyagi, Saki Gotoh, Takano Ohta, Takao Kataoka, Kazumichi Furuyama and Shigeru Taketani

"The decrease of mitochondrial utilization of iron by the knockdown of mitoferrin-2 and frataxin also enhanced the ALA effect."

PEP-1-Frataxin Significantly Increases Cell Proliferation and Neuroblast Differentiation by Reducing Lipid Peroxidation in the Mouse Dentate Gyrus.

Neurochem Res. 2011 Sep 1,

Kim W, Kim DW, Shin BN, Yoo DY, Nam SM, Kim MJ, Choi JH, Yoon YS, Won MH, Choi SY, Hwang IK.

Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, South Korea.

Keywords: Frataxin, cell proliferation, neuroblast differentiation, PEP-1-frataxin fusion protein, decreasing lipid peroxidation, blood-brain barrier, dentate gyrus.

Articulatory Kinematics in the Dysarthria Associated with Friedreich's Ataxia.

Motor Control. 2011 Jul;15(3):376-89.

Folker JE, Murdoch BE, Cahill LM, Rosen KM, Delatycki MB, Corben LA, Vogel AP.

School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Qld, Australia.

KEYWORDS: Electromagnetic articulography (EMA), dysarthria, Friedreich's ataxia (FRDA).