CeNeRx BioPharma Obtains Rights To Novel Drug Candidate For Prevention And Treatment Of Neurodegeneration Disorders
Medical News Today, Article Date: 17 Jun 2009 - 3:00 PDT
Full Text: http://www.medicalnewstoday.com/articles/154197.php
Keywords: central nervous system , neuropathies, neurodegenerative disorders, CXB909, nerve growth factor (NGF), Phase l trial , blood brain barrier.
Press realease of CeNeRx Biopharma: http://cenerx.com/News/releases/16a-JUN-09.pdf
Wednesday, June 17, 2009
Tuesday, June 16, 2009
DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice
J. Clin. Invest. doi:10.1172/JCI39038
Copyright © 2009, The American Society for Clinical Investigation
DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice
Tomoya Terashima1, Kazuhiro Oka1,2, Angelika B. Kritz3, Hideto Kojima2, Andrew H. Baker3 and Lawrence Chan1,2
1Department of Medicine and 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. 3British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Address correspondence to: Lawrence Chan, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. Phone: (713) 798-4478; Fax: (713) 798-8764; E-mail: lchan@bcm.tmc.edu.
Published June 15, 2009
Full text: http://www.jci.org/articles/view/39038
Keywords: sensory neuronopathies, painful , DRG, therapeutic genes , dorsal root ganglion , adenoviruses, mice.
Copyright © 2009, The American Society for Clinical Investigation
DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice
Tomoya Terashima1, Kazuhiro Oka1,2, Angelika B. Kritz3, Hideto Kojima2, Andrew H. Baker3 and Lawrence Chan1,2
1Department of Medicine and 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. 3British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Address correspondence to: Lawrence Chan, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. Phone: (713) 798-4478; Fax: (713) 798-8764; E-mail: lchan@bcm.tmc.edu.
Published June 15, 2009
Full text: http://www.jci.org/articles/view/39038
Keywords: sensory neuronopathies, painful , DRG, therapeutic genes , dorsal root ganglion , adenoviruses, mice.
Therapeutic Delivery Of A Gene To Dysfunctional Nerves
Therapeutic Delivery Of A Gene To Dysfunctional Nerves
ScienceDaily (June 15, 2009) — In many sensory neuronopathies, painful conditions affecting sensory nerves outside the brain and spinal cord, the affected nerves are in a region known as the DRG. These conditions are difficult to treat. However, researchers have now developed an approach to target therapeutic genes to DRG nerves, and used it to reduce sensory nerve dysfunction in a mouse model of Sandhoff disease, an inherited condition in which many nerves, including those in the DRG, are affected.
Full Text http://www.sciencedaily.com/releases/2009/06/090615171509.htm
Keywords: sensory neuronopathies, painful , DRG, therapeutic genes , dorsal root ganglion , adenoviruses, mice.
ScienceDaily (June 15, 2009) — In many sensory neuronopathies, painful conditions affecting sensory nerves outside the brain and spinal cord, the affected nerves are in a region known as the DRG. These conditions are difficult to treat. However, researchers have now developed an approach to target therapeutic genes to DRG nerves, and used it to reduce sensory nerve dysfunction in a mouse model of Sandhoff disease, an inherited condition in which many nerves, including those in the DRG, are affected.
Full Text http://www.sciencedaily.com/releases/2009/06/090615171509.htm
Keywords: sensory neuronopathies, painful , DRG, therapeutic genes , dorsal root ganglion , adenoviruses, mice.
Saturday, June 13, 2009
Fine Mapping of Gene Regions Regulating Neurodegeneration
OPEN ACCES
PLoS ONE, Full text
PLoS ONE, Full text
Fine Mapping of Gene Regions Regulating Neurodegeneration
Maria Swanberg1,2, Karin Harnesk1#, Mikael Ström1#, Margarita Diez1, Olle Lidman1, Fredrik Piehl1*1 Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden, 2 Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden
Abstract
BackgroundDamage to nerve cells and axons leading to neurodegeneration is a characteristic feature of many neurological diseases. The degree of genetic influence on susceptibility to axotomy-induced neuronal death has so far been unknown. We have examined two gene regions, Vra1 and Vra2, previously linked to nerve cell loss after ventral root avulsion in a rat F2 intercross between the DA and PVG inbred rat strains.
Methodology/Principal Findings
In this study, we use two generations (G8 and G10 cohorts) of an advanced intercross line between DA and PVGav1 to reproduce linkage to Vra1 and to fine-map this region. By isolating the effect from Vra1 in congenic strains, we demonstrate that Vra1 significantly regulates the loss of motoneurons after avulsion. The regulatory effect mediated by Vra1 thus resides in a congenic fragment of 9 megabases. Furthermore, we have used the advanced intercross lines to give more support to Vra2, originally detected as a suggestive QTL.
Conclusions/Significance
The results demonstrated here show that naturally occurring allelic variations affect susceptibility to axotomy-induced nerve cell death. Vra1 and Vra2 represent the first quantitative trait loci regulating this phenotype that are characterized and fine mapped in an advanced intercross line. In addition, congenic strains provide experimental evidence for the Vra1 effect on the extent of injury-induced neurodegeneration. Identification of the underlying genetic variations will increase our understanding of the regulation and mechanisms of neurodegeneration.
Citation: Swanberg M, Harnesk K, Ström M, Diez M, Lidman O, et al. (2009) Fine Mapping of Gene Regions Regulating Neurodegeneration. PLoS ONE 4(6): e5906. doi:10.1371/journal.pone.0005906
Editor: Rafael Linden, Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Biofísica da UFRJ, Brazil
Received: March 19, 2009; Accepted: May 19, 2009; Published: June 15, 2009
Copyright: © 2009 Swanberg et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This study was supported by the 6th Framework Program of the European Union, NeuroproMiSe, LSHM-CT-2005-018637 and EURATools, LSHG-CT-2005019015, the Swedish Research Council, Wadsworth Foundation, the Swedish Society for Medical Research, the Swedish Brain Foundation, the Nils and Bibbi Jenssens Foundation, the Montel Williams MS Foundation, the GV80 Foundation, the Soderberg Foundation, and the Swedish Association of Persons with Neurological Disabilities. The funders had no role in study design, data collection or analysis, manuscript preparation or decision to publish.
Competing interests: The authors have declared that no competing interests exist.
* E-mail: fredrik.piehl@ki.se
Thursday, June 11, 2009
Two Signals -- From Within And Out Of Cell -- Specify Motor Neuron Differentiation
ScienceDaily (June 10, 2009) -Science News
Two Signals -- From Within And Out Of Cell -- Specify Motor Neuron Differentiation
ScienceDaily (June 10, 2009) — Two signals – an external one from retinoic acid and an internal one from the transcription factor Neurogenin2 – cooperate to activate chromatin (the basic material of chromosomes) and help determine that certain nerve progenitor cells become motor neurons, said researchers from Baylor College of Medicine in a report in the current issue of the journal Neuron.
Full text: http://www.sciencedaily.com/releases/2009/06/090610124411.htm
Keywords: motor neurons , stem cells, Neurogenin2, retinoic acid , histone acetyltransferase , histones , transcription , nerve progenitor cells, muscular dystrophies
Two Signals -- From Within And Out Of Cell -- Specify Motor Neuron Differentiation
ScienceDaily (June 10, 2009) — Two signals – an external one from retinoic acid and an internal one from the transcription factor Neurogenin2 – cooperate to activate chromatin (the basic material of chromosomes) and help determine that certain nerve progenitor cells become motor neurons, said researchers from Baylor College of Medicine in a report in the current issue of the journal Neuron.
Full text: http://www.sciencedaily.com/releases/2009/06/090610124411.htm
Keywords: motor neurons , stem cells, Neurogenin2, retinoic acid , histone acetyltransferase , histones , transcription , nerve progenitor cells, muscular dystrophies
Saturday, June 6, 2009
Oligomeric yeast frataxin drives assembly of core machinery for mitochondrial iron-sulfur cluster synthesis.
J Biol Chem. 2009 Jun 2.
Li H, Gakh O, Smith DY 4th, Isaya G.
Keywords: iron-sulfur clusters, iron, sulfur, Yfh1, Nfs1-Isd11, Isu1, oligomerization, oxidation, mechanism, mitochondrial ISC synthesis..
Oligomeric yeast frataxin drives assembly of core machinery for mitochondrial iron-sulfur cluster synthesis.
Li H, Gakh O, Smith DY 4th, Isaya G.
Mayo Clinic, College of Medicine, United States.
Mitochondrial biosynthesis of iron-sulfur clusters (ISC)(1) is a vital process involving the delivery of elemental iron and sulfur to a scaffold protein .....Keywords: iron-sulfur clusters, iron, sulfur, Yfh1, Nfs1-Isd11, Isu1, oligomerization, oxidation, mechanism, mitochondrial ISC synthesis..
Neural stem cell boosting chemical that generate new neurons - received U.S. patent allowance
"Stem Cell Research Blog" 06 Jun 2009 12:43 pm
Neural-stem-cell-boosting-chemical-that-generate-new-neurons-received-us-patent-allowance
The U.S. Patent and Trademark Office (USPTO) have delivered a notice of allowance to Neuralstem, Inc. for a patent on four new chemicals that can boost the generation of new neurons. .....
Keywords: Neuralstem Inc, patent, neurons, neurogenic activity, drugs, human neural stem cells, hippocampus.
Neural-stem-cell-boosting-chemical-that-generate-new-neurons-received-us-patent-allowance
The U.S. Patent and Trademark Office (USPTO) have delivered a notice of allowance to Neuralstem, Inc. for a patent on four new chemicals that can boost the generation of new neurons. .....
Keywords: Neuralstem Inc, patent, neurons, neurogenic activity, drugs, human neural stem cells, hippocampus.
Friday, June 5, 2009
Subjective Improvement in Proprioception in 2 Patients With Atypical Friedreich Ataxia Treated With Varenicline (Chantix)
Journal of Clinical Neuromuscular Disease:
June 2009 - Volume 10 - Issue 4 - pp 191-193
doi: 10.1097/CND.0b013e3181910074
Subjective Improvement in Proprioception in 2 Patients With Atypical Friedreich Ataxia Treated With Varenicline (Chantix)
Zesiewicz, Theresa A MD, FAAN; Sullivan, Kelly L MSPH; Gooch, Clifton L MD; Lynch, David R MD, PhD
Keywords: Friedreich ataxia , proprioceptive improvements , varenicline (Chantix), smoking cessation.
June 2009 - Volume 10 - Issue 4 - pp 191-193
doi: 10.1097/CND.0b013e3181910074
Subjective Improvement in Proprioception in 2 Patients With Atypical Friedreich Ataxia Treated With Varenicline (Chantix)
Zesiewicz, Theresa A MD, FAAN; Sullivan, Kelly L MSPH; Gooch, Clifton L MD; Lynch, David R MD, PhD
Keywords: Friedreich ataxia , proprioceptive improvements , varenicline (Chantix), smoking cessation.
Thursday, June 4, 2009
Small Molecules Mimic Natural Gene Regulators
Medical News Today: Article Date: 04 Jun 2009 - 7:00 PDT
Source: Nancy Ross-Flanigan. University of Michigan
.../...
These molecules can help scientists probe the transcription process and perhaps eventually be used to correct diseases that result from errors in gene regulation.
.../...
Keywords: turning genes, cancer, diabetes, gene expression, transcriptional activators , CBP.
Original work:( http://pubs.acs.org/doi/abs/10.1021/cb900028j?prevSearch=David+Wemmer&searchHistoryKey= )
Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors
Source: Nancy Ross-Flanigan. University of Michigan
Small Molecules Mimic Natural Gene Regulators
In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes ........../...
These molecules can help scientists probe the transcription process and perhaps eventually be used to correct diseases that result from errors in gene regulation.
.../...
Keywords: turning genes, cancer, diabetes, gene expression, transcriptional activators , CBP.
Original work:( http://pubs.acs.org/doi/abs/10.1021/cb900028j?prevSearch=David+Wemmer&searchHistoryKey= )
Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors
Sara J. Buhrlage†, Caleb A. Bates‡, Steven P. Rowe†, Aaron R. Minter†, Brian B. Brennan†, Chinmay Y. Majmudar†, David E. Wemmer§, Hashim Al-Hashimi†
and Anna K. Mapp†‡¶*
and Anna K. Mapp†‡¶* † Department of Chemistry ‡ Department of Medicinal Chemistry Department of Biophysics ¶ Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 § Department of Chemistry, University of California, Berkeley, California 94720
Department of Biophysics ¶ Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 § Department of Chemistry, University of California, Berkeley, California 94720ACS Chem. Biol., 2009, 4 (5), pp 335–344
DOI: 10.1021/cb900028j
Publication Date (Web): April 6, 2009
Copyright © 2009 American Chemical Society
Wednesday, June 3, 2009
Friedreich ataxia (fa) associated with diabetes mellitus type 1 and hyperthrophic cardiomyopathy.
Friedreich ataxia (fa) associated with diabetes mellitus type 1 and hyperthrophic cardiomyopathy.
Bosn J Basic Med Sci. 2009 May;9(2):107-10.
Gucev Z, Tasic V, Jancevska A, Popjordanova N, Koceva S, Kuturec M, Sabolic V.
Faculty of Medicine Skopje, St. Cyril and Methodius University, 50 Divizija BB, 1000 Skopje, Macedonia.
Progressive signs of ataxia in a eight years old girl prompted neurological investigation. The girl had unstable gait .....
Keywords: Friedreich ataxia, dysarthria, pes cavus, positive Babinski sign, scoliosis, diabetic ketoacidosis, GAA trinucleotide repeat, sinus bradycardia, hyperthrophic cardiomyopathy, beta blocker, insulin.
Bosn J Basic Med Sci. 2009 May;9(2):107-10.
Gucev Z, Tasic V, Jancevska A, Popjordanova N, Koceva S, Kuturec M, Sabolic V.
Faculty of Medicine Skopje, St. Cyril and Methodius University, 50 Divizija BB, 1000 Skopje, Macedonia.
Progressive signs of ataxia in a eight years old girl prompted neurological investigation. The girl had unstable gait .....
Keywords: Friedreich ataxia, dysarthria, pes cavus, positive Babinski sign, scoliosis, diabetic ketoacidosis, GAA trinucleotide repeat, sinus bradycardia, hyperthrophic cardiomyopathy, beta blocker, insulin.
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